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Sunday, July 19, 2020 | History

3 edition of Characterization of the Ah receptor found in the catalog.

Characterization of the Ah receptor

Characterization of the Ah receptor

project summary

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  • 15 Currently reading

Published by U.S. Environmental Protection Agency, Health Effects Research Laboratory in Research Triangle Park, NC .
Written in English

    Subjects:
  • Receptor-ligand complexes.

  • Edition Notes

    StatementStephen H. Safe.
    ContributionsHealth Effects Research Laboratory (Research Triangle Park, N.C.)
    The Physical Object
    FormatMicroform
    Pagination1 v.
    ID Numbers
    Open LibraryOL17677759M

    Bank I, Cohen L, Kneller A, de Rosbo NK, Book M, Ben-Nun A () Aberrant T-Cell Receptor Signalling of Interferon-γ- and Tumour Necrosis Factor-α-Producing Cytotoxic CD8+Vδ1/Vβ16 T Cells in a Patient with Chronic Neutropenia. Scand J Immunol doi: /jx: 4. Linked expression of Ah receptor, ARNT, CYP1A1, and CYP1B1 in rat mammary epithelia, in vitro, is each substantially elevated by specific extracellular matrix interactions that precede branching morphogenesis. Toxicol. Sci. 82, 46 –

    Book Title: Androgens and Androgen Receptor: Mechanisms, Functions and Clinical Application. Author List: Collins L and Chang C Edited By: (Chang C ed). Published By: Kluwer, USA Chapter Title: "Interaction of cell cycle regulatory proteins with the androgen receptor." Book Title: Steroid hormones and cell cycle regulation.   Functional Characterization of C-terminal Ryanodine Receptor 1 Variants Associated with Central Core Disease or Malignant Hyperthermia Schiemann AH, Pollock N, Stowell KM. Functional characterisation of the RW ryanodine receptor variant associated with malignant hyperthermia susceptibility. For editorial issues, permissions, book Cited by: 3.

    Some of the most toxic HAHs cause toxicity by binding to and activating the aryl hydrocarbon receptor (Ah receptor or AHR). The AHR is a ligand-activated transcription factor and the first protein in a signal transduction pathway that c ulminates in the altered expression of genes involved in the control of cell growth and differentiation. In recent years, among the most promising new targets for cancer treatment, there is a growing interest in the insulin receptor (IR). IR belongs to a family of receptor tyrosine kinases (RTKs) that also includes the insulin-like growth factor 1 receptor (IGF-1R). Both, IR and IGF-1R, are tetrameric proteins sharing ≃60% of amino acid by:


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Characterization of the Ah receptor Download PDF EPUB FB2

The aryl hydrocarbon receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as the regulator of enzymes such as cytochrome Ps that metabolize these s: AHR, bHLHe76, aryl hydrocarbon.

Get this from a library. Characterization of the Ah receptor: project summary. [Stephen H Safe; Health Effects Research Laboratory (Research Triangle Park, N.C.)].

AH receptor-interacting protein (AIP) also known as aryl hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, or HBV X-associated protein 2 (XAP-2) is a protein that in humans is encoded by the AIP gene. The protein is a member of the FKBP s: AIP, ARA9, FKBP16, FKBP37.

The Receptors, Volume II deals with receptors for somatostatin, vitamin D, insulin, and animal Characterization of the Ah receptor book, as well as for the?2-adrenergic and Ah systems. The significance of translational modifications of receptor ligands is discussed, along with the.

The Ah receptor (AhR) is a ligand-dependent transcription factor that mediates a wide range of biological and toxicological effects from exposure to structurally diverse synthetic and naturally occurring chemicals. The detailed protocols described here provide step-by-step instructions for detection and characterization of activators of AhR Cited by: 4.

Many recent studies have suggested that activation of the aryl hydrocarbon receptor (AhR) reduces immune responses, thus suppressing allergies and autoimmune diseases.

In our continuing study on natural AhR agonists in foods, we examined the influence of 37 health food materials on the AhR using a reporter gene assay, and found that aqueous ethanol extracts of Cited by: 6. Influence of oxidative stress on aryl hydrocarbon receptor signaling and excluded volume plots provide for a more detailed characterization of the molecular binding domain of the Ah receptor.

An orphan receptor strategy has served as a powerful tool to discover novel peptides or peptide hormones (Civelli et al., ). This method has led to the identification of several important bioactive peptides, such as nociceptin/orphanin FQ, orexin/hypocretin, prolactin-releasing peptide, apelin, metastin (kisspeptin), neuropeptide B, and.

Bank I, Book M, Cohen L, Kneller A, Rosental E, Pras M, Bassat IB, Ben-Nun A. Expansion of a unique subpopulation of cytotoxic T cells that express a C alpha V delta 1 T-cell receptor gene in a patient with severe persistent neutropenia.

Blood. ; –Cited by: Receptor-mediated in vitro bioassay for characterization of Ah-R-active compounds and activities in sediment from Korea Article in Chemosphere 62(8) March with 21 Reads. @article{osti_, title = {Functional characterization of estrogen receptor subtypes, ER{alpha} and ER{beta}, mediating vitellogenin production in the liver of rainbow trout}, author = {Leanos-Castaneda, Olga and Kraak, Glen van der}, abstractNote = {The estrogen-dependent process of vitellogenesis is a key function on oviparous fish reproduction and it has been.

@article{osti_, title = {Characterization and distribution of trace organic contaminants in sediment from Masan Bay, Korea. 2: In vitro gene expression assays}, author = {Khim, J S and Villeneuve, D L and Kannan, K and Koh, C H and Giesy, J P}, abstractNote = {Extracts of sediment collected from Masan Bay, Korea were fractionated using Florisil columns, Fractions.

The Ah receptor (AHR) has been studied for almost five decades. Yet, we still have many important questions about its role in normal physiology and development. Moreover, we still do not fully understand how this protein mediates the adverse effects of a variety of environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), the chlorinated dibenzo-p.

Hecker M., Giesy J.P. () Effect-Directed Analysis of Ah-Receptor Mediated Toxicants, Mutagens, and Endocrine Disruptors in Sediments and Biota. In: Brack W. (eds) Effect-Directed Analysis of Complex Environmental Contamination.

The Handbook of Environmental Chemistry, vol Springer, Berlin, Heidelberg. First Online 29 March Cited by: Characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: use of chemical crosslinking and a monoclonal antibody directed against a 59 Cited by: 4.

Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.

Search for more papers by this authorCited by: Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition.

A zebrafish M 2 muscarinic acetylcholine receptor (mAChR) gene was cloned. It encodes amino acids in a single exon. The derived amino acid sequence is % identical to its human homologue.

Competitive binding studies of the zebrafish M 2 receptor and [3 H]‐NMS gave negative log dissociation constants (pK i) for each antagonist as follows: atropine Cited by: The ability of the parathyroid cell to sense minute fluctuations in the extracellular ionized calcium concentration (Ca2+o) is essential for maintaining mineral ion homeostasis.

However, the mechanisms(s) through which the parathyroid cell and other cells recognize and respond to changes in Ca2+o has remained unclear. We recently isolated a cDNA encoding a Ca2+o Cited by: This book details a growing body of data indicating that noncancer health effects—developmental, reproductive, neurologic, and immunologic toxicities—might pose a greater health concern than cancer from dioxin exposure.

The authors agree that most, if not all, dioxin effects require binding to the aryl hydrocarbon (Ah) receptor. HISTORY OF DEVELOPMENT IN ASTHMA DRUG COMPOUNDS In finding the treatment of asthma, more than hundred years of research has been put into the development of introducing the right agent triggering a specific response; Salbutamol as a ventolin inhaler, a?

2-adrenoceptor agonist. This research report addresses the main compound that .After [3 H-1,6]-2,3,7,8-tetrachlorodibenzo-p-dioxin (3 H-TCDD) is given in vivo, the receptor in Ah b /Ah b and Ah b /Ah d mice is detectable in the cytoplasm and nucleus; in Ah d /Ah d mice the receptor is not measurable in the cytosol, but is found in the nucleus at levels one fourth to one fifth of those in Ah b /Ah b mice.

1. Introduction. Breast cancer (BC) is a global public health issue and the most commonly diagnosed neoplasm in the world [].The expression of estrogen receptor α (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) is widely accepted as prognostic and predictive markers and thus considered suitable to guide Cited by: 2.