2 edition of Antigenic analysis of nephritogenic and non-nephritogenic streptococci found in the catalog.
Antigenic analysis of nephritogenic and non-nephritogenic streptococci
Alice Louise Vreeland
Written in English
|Statement||by Alice Louise Vreeland|
|The Physical Object|
|Pagination||39 leaves :|
|Number of Pages||39|
Binding of i Human IgG to Nephritogenic and Non-Nephritogenic Group A Streptococci 70 Interaction of Nephritogenic and Non-Nephritogenic Group A Streptococci with Hunan IgG Subclasses 73 v LIST OF FIGURES FIGURE Page Schematic representation of the immunoblotting procedure for detection of surface Fc receptors 16 The precise mechanism by which nephritogenic streptococci induce renal injury is not fully understood. An immunemediated humoral mechanism is strongly indicated by the renal deposition of immunoglobulins and complement, presence of discrete electron-dense deposits in the sub-epithelial space, low serum complement levels in the acute phase, and high serum levels of .
nephritogenic: (ne-frit'ō-jen'ik), Causing nephritis; said of conditions or agents. [nephritis + G. genesis, production]. Nephritogenic definition at , a free online dictionary with pronunciation, synonyms and translation. Look it up now!
85 cases of sore throat occurred in a Rumanian town during two summer months. Acute glomerulonephritis occurred as a late complication, in the second and third weeks of the illness, in about onethird of these patients. Because early diagnosis was not made penicillin was given to a few patients only. Urine, faeces and throat swabs were examined and lymph node biopsy was . nephritogenic definition: Adjective (comparative more nephritogenic, superlative most nephritogenic) 1. That causes nephritis.
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The genus Streptococcus, a heterogeneous group of Gram-positive bacteria, has broad significance in medicine and industry. Various streptococci are important ecologically as part of the normal microbial flora of animals and humans; some can also cause diseases that range from subacute to acute or even chronic.
Among the significant human diseases attributable to streptococci. A new nephritogenic streptococcus - Volume 67 Issue 4 - Eugenia Duca, Gr.
Teodorovici, C. Radu, Alla Antigenic analysis of nephritogenic and non-nephritogenic streptococci book, Paula Talaşman-Niculescu, Elisabeta Bernescu, C.
Feldi Cited by: Velibor Tasic, in Comprehensive Pediatric Nephrology, PATHOGENESIS. It is clear that PSGN is an immune complex disease, but the nephritogenic antigen is still a matter of debate. 25, 26 The proposed mechanisms are (1) deposition of circulating immune complexes containing nephritogenic antigen in glomeruli, (2) implantation of the nephritogenic antigen into.
streptococci are usually associated with acute glomerulonephritis as a late non- A new nephritogenic streptococcus The antistreptolysin-0 titration in patients' sera was performed by the method of Rantz & Randall (), using streptolysin-0 supplied by the Institute 'Dr by: Abstract.
Ever since the group A Streptococcus was linked as the causative agent of acute Rheumatic Fever (RF) and of Acute Glomerulonephritis (AGN) the vexing question as to whether all, or only some streptococcci cause either, or both, of these diseases has been asked.
AGN is a self limiting disease for which the prognosis is usually good. In contrast, acute RF carries the Cited by: 6. Taken together, these findings indicate an underlying conservation of the tertiary structure of the various M protein serotypes, despite the complexity in their antigenic variation and suggest that the nephritogenic M protein serotypes M1 and M49 may be further apart evolutionarily from the rheumatogenic serotypes 5, 6, and The disease is a consequence of previous throat or skin infection with nephritogenic strains of group A beta hemolytic streptoccoci and rarely with group C.
Acute post-streptococcal glomerulonephritis (APSGN) is a nonsuppurative complication of infection by group A streptococci. An immune complex pathogenesis has been widely accepted since the landmark studies of Schick in 1, and the proposal that there are “nephritogenic” streptococcal strains was advanced more than half a century ago 2, 3.
Streptococcus pyogenes (Group A streptococcus) is a Gram-positive, nonmotile, nonsporeforming coccus that occurs in chains or in pairs of dual cells are round-to-ovoid cocci, micrometer in diameter (Figure 1).
Streptococci divide in one plane and thus occur in pairs or (especially in liquid media or clinical material) in chains of varying lengths. In recent years, 2 streptococcal antigens, the cationic cysteine proteinase exotoxin B (SPE B) and the plasmin receptor, a glyceraldehyde phosphate dehydrogenase (Plr, GAPDH) have attracted attention because: (1) they were localized in glomeruli in patients with acute post-streptococcal glomerulonephritis (APSGN); and (2) serum antibody to.
Comments on nephritogenic. What made you want to look up nephritogenic?Please tell us where you read or heard it (including the quote, if possible). Sequence Polymorphism of Streptokinases At the time of writing this paper, attempts to broaden the sequence information and to include in these analyses SKases from both nephritogenic and non-nephritogenic.
strains for comparison have revealed the complete primary structures for 5 SKases (Fig. Holm SE, Braun D, Jönsson J. Antigenic factors common to human kidney and nephritogenic and non-nephritogenic streptococcal strains.
Int Arch Allergy Appl Immunol. ; 33 (2)– Hryniewicz W, Lipinski B, Jeljaszewicz J. Nature of the interaction between M protein of Streptococcus pyogenes and fibrinogen. Holm SE, Braun D, Jönsson J.
Antigenic factors common to human kidney and nephritogenic and non-nephritogenic streptococcal strains. Int Arch Allergy Appl Immunol. ; 33 (2)– Kaplan MH. The cross-reaction of group A streptococci with heart tissue and its relation to induced autoimmunity in rheumatic fever.
Ten years later Ophuls (3) demonstrated that only certain strains of streptococci appeared to have the nephritogenic capacity in man. This was later on confirmed by Rammelkamp et al. (4,5) reporting high incidence of acute post-streptococcal glomerulonephritis in epidemics caused by certain M-types of group A streptococci.
The non-nephritogenic M12 S. pyogenes strain MGAS was omitted from this analysis since its sequence is % identical to that of the nephritis-associated M12 st rain MGAS fection by group A streptococci. An immune complex pathogenesis has been widely accepted since the land-mark studies of Schick in , and the proposal that there are “nephritogenic” streptococcal strains was advanced more than half a century ago [2, 3].
How-ever, the nature of the putative streptococcal antigen. Harrell WK, Ashworth H, Davis RE., 2nd Cross-protective antigens of group A streptococci types 3 and 31 and types 46 and Infect Immun.
Jul; 4 (1)– [PMC free article] Potter EV, Ortiz JS, Sharrett AR, Burt EG, Bray JP, Finklea JF, Poon-King T, Earle DP. Changing types of nephritogenic streptococci in Trinidad. J Clin Invest. The relation of nephritis-associated plasmin receptor (NAPlr) as a nephritogenic antigen in group A streptococci (GAS), to acute poststreptococcal glomerulonephritis (APSGN) and the.
Figure 4. Immunoelectronmicroscopy-immune gold staining. (A) Staining for human C3, extensive, diffuse staining in subepithelial hump.(B) Staining for human IgG, scattered staining in hump.(C) Staining for zymogen/SPE B, patchy distribution of antigen in hump.(D) Composite of A, B, and C, gold particles replaced with colored spots, as indicated, to allow better comparison of their.
Genomic sequencing of nephritogenic strains of streptococci may lead to the discovery of new nephritogenic antigen candidates in conserved and differing regions .Antigenic Factors Common to Human Kidney and Nephritogenic and Non-Nephritogenic Streptococcal Strains cell membrane of nephritogenic streptococci were shown to be immunologically cross.
Classification and Antigenic Types Streptococci are classified on the basis of colony morphology, hemolysis, biochemical reactions, and (most definitively) serologic specificity.
They are divided into three groups by the type of hemolysis on blood agar: 1. β-hemolytic (clear, complete lysis of red cells), 2. α- hemolytic (a partial or.